18
Researchers
16
Different services
7
Advanced facilities

Medicinal Chemistry for drug discovery

Our medicinal chemistry research groups are capable of applying computer chemistry to assist compound design process.

We apply advanced drug discovery technologies, including proteolysis-targeting chimera (PROTAC), DNA-encoded chemical library (DEL) and antibody drug conjugation (ADC).

In the filed of the medicianl chemistry for drug discovery, we offer assay development, target identification, and lead optimization, to ensure molecules with druglike physicochemical properties and patentability for your success.

We acknowledge that each drug discovery project is unique, and our researchers have experience in the most diverse therapeutic area, mechanism of action, mode of delivery, to develop new valuable clinical candidates.

We can provide medicinal chemistry expertise to help the progress of your project under the guidance of our team of academic researchers, providing an unique in-depth understanding of all scientific disciplines to support the drug discovery process.

Our researchers have built a strong track record in developing small-molecule drug candidates across several key therapeutic areas.

We also enable the development of innovative therapeutic strategies such as proteolysis targeting chimeras (PROTACs), antibody-drug conjugates (ADCs), peptidomimetics and PEGylated therapeutics.

Our services

DSF’s Medicinal Chemistry fo drug discovery services includes:

  1. Feasibility assessment of new drug targets
  2. High-throughput screening and discovery of active compounds based on structural design
  3. SAR-based compound synthesis and SAR-based optimization
  4. Establishment of specific compound libraries
  5. Synthesis of proteolysis targeting chimera (PROTAC) molecules
  6. Synthesis of lipids, glycolipids, and phospholipids
  7. Screening of new hit compounds from DEL (from active compounds to discovery of lead compounds)
  8. Synthesis of antibody-drug conjugates (ADC)
  9. Synthesis of PEGylated small molecules
  10. Synthesis of PEGylated antibodies or proteins
  11. Synthesis of custom polymer-protein conjugates
  12. Synthesis, discovery, and optimization of hit compounds
  13. Research on SAR
  14. Processes from optimization of lead compounds to determination of preclinical drug candidates
  15. Multi-parameter lead optimization for desired target molecule profiles (synthesis, discovery, and structural optimization of lead compounds)
  16. Drug-target complex formation. Characterization and quantification

Are you interested in our Medicinal Chemistry for drug discovery services?

Ask for a quote