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Instruments available
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Services offered
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Researchers available

Advanced drug delivery

Advanced drug delivery systems (ADDS) are pharmaceutical formulations in which excipients are designed and/or combined to influence the release, the activity and/or the in vivo biodistribution of active ingredients.

The general goal of advanced drug delivery is to overcome some of the limitations of conventional dosage forms, for example, by modifying dissolution patterns or pharmacokinetic and biodistribution profiles or by improving stability or patient compliance.

Geometries of our Advanced drug delivery systems

Advanced drug delivery systems encompass a large number of geometries.
Specifically, at our department the advanced drug delivery technology experts possess specific know-how on a number of ADDS, among which lipid formulations for oral administration of Biopharmaceutical Classification System (BCS) Class II or IV active ingredients (SEDDS, SMEEDS, etc.), liposomes, solid lipid nanoparticles (SLNP), polymer (e.g. PLGA ) nanoparticles, protein nanoparticles, polymeric micelles, polymer conjugates (e.g. polymers linked to proteins or low molecular weight drugs), antibody drug conjugates, sol-gel based silica micro and nanoparticles, viruses.

We help you identifying technologies and processes

The overall technologies mastered by our experts can be applied to formulate active ingredients with different physico-chemical properties (from low molecular weight compounds to complex macromolecules and nucleic acids), to modify (accelerate, slow down or sustain) the release profiles of active molecules, and/or to improve their stability or to provide specific tissue or cell targeting properties.

Our experts can help identifying the most suitable formulations/technologies and/or processes to fulfill customer needs, by either performing exploratory studies at the technology department labs or by providing consultancy at customer sites.

Optimization of advanced drug delivery encompasses excipients and process optimization, evaluation of drug release, quality control and stability testing for shelf live prediction.

Instrumentation available for ADD development

  1. Microfluidic nanoassembler
  2. Tangential flow filtration (Akta Flux, Cytiva)
  3. Turbomixers
  4. Spray drier (Buchi)
  5. Freeze-dryier (Lyovapor L-200, Buchi)
  6. Controlled humidity and temperature chamber
  7. Dynamic light scattering (Malvern Zetasizer)
  8. Surface plasmon resonance (Biacore)
  9. Mass spectrometry

Services/technologies available (ADDS)

  1. Lipid based formulations for oral administration;
  2. Liposome formulations:
  3. Solid lipid nanoparticle formulations;
  4. Formulation of polymeric micelles;
  5. Formulation of polymer nanoparticles;
  6. Formulation of protein nanoparticles;
  7. Formulation of silica based micro and nanoparticles;
  8. Formulations for slow/sustained release of proteins;
  9. Formulations for slow/sustained release of low molecular weight active agents;
  10. Synthesis of polymer-drug/protein conjugates;
  11. Optimization of antibody drug conjugates (ADCs)
  12. Development of viral carriers for gene therapy
  13. Dissolution tests
  14. Preliminary stability studies

Do you need to identify technologies and process to design your Advanced Drug Delivery Systems?

Ask for a consultation