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Pharmacology Research

The Pharmacology & Toxicology Research Teams @DSF possess solid technical expertise with extensive experience in consulting, designing and conducting research studies for determining the therapeutic & safety properties of small molecule and biologic drugs.

The research conducted by our scientists include, but are not limited to, neuropharmacology, cardiovascular, cancer and gastrointestinal pharmacology. 

Molecular and genetic in vitro and in vivo models, as well as a wide variety of techniques combined with integrated system approaches, are utilized for studying small molecule and biologic drugs. The continued contributions by the Pharmacology & Toxicology Research Teams and their trainees have been well-recognized at both the national and international levels.

Pharmacodynamics & Pharmacokinetics

  1. Concentration-response curves of new chemical and biological entities
  2. Dose-effect curves of new chemical and biological entities
  3. Gender difference/dose correlation/accumulation analysis
  4. Epithelial permeability studies
  5. Plasma stability tests
  6. Blood to Plasma Ratio
  7. Determination of plasma protein binding rate
  8. Tissue distribution
  9. Bioavailability
  10. Plasma PK parameters
  11. Metabolic stability (liver microsomes, S9, Cytosol, hepatocytes and blood)
  12. Identification of drug metabolites 
  13. Active ingredient/prodrug/metabolite monitoring
  14. Estimation of metabolic pathway
  15. CYP enzyme inhibition (DDI and TDI)
  16. CYP enzyme induction 
  17. Drug-drug interaction
  18. Routes of excretion
  19. Liver microsomal metabolism tests
  20. Blood Brain Barrier
  21. Excretion Research
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Preclinical Research

The Pharmacology & Toxicology Research Teams @DSF focus on the development of effective therapeutic strategies availing of pharmacological and functional studies, medicines repositioning, biologic therapy, multiomics methods, as essential element for personalized medicine improvement. Specific capabilities include: 

  1. Identification of molecular targets of protein-mediated diseases (genetic diseases and diseases caused by aberrant structure proteins)
  2. Identification of protein markers in biological fluids, cells, tissues, and extracellular vesicles both in patients and animal model
  3. Tumor Models
  4. Digestive System Disease Models
  5. Endocrine & Metabolic Disease Models
  6. Inflammatory & Immune Diseases Models
  7. Neural System Disease Models
  8. Behavioral Tests
  9. Histopathological Studies
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Preclinical safety assessment

With experienced scientists, The Pharmacology & Toxicology Research Teams @DSF assess drug efficacy and safety assessments in the most qualified manner while meeting the European regulatory standard. 

  1. Single dose toxicity tests 
  2. Repeated dose toxicity tests 
  3. Toxicokinetic analysis
  4. Genetic toxicity tests
  5. Immunogenicity tests
  6. Antibody-drug conjugates (ADC) safety evaluation
  7. In Vivo Toxicology
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Clinical Research

The Pharmacology & Toxicology Research Teams @DSF provide pharmaceutical know-how to conduct and support clinical/translational trials, and postmarketing assessment of medicinal drugs as well as are specialized in conducting pharmacology studies on experimental therapeutics.

  1. Conduct of Pharmacoepidemiology studies
  2. Conduct of Clinical Outcomes studies
  3. Program and protocol development and support
  4. Bioanalytical method development
  5. Bioanalytical method validation
  6. Blood/Plasma/Serum sample analysis
  7. Tissue sample analysis / tissue distribution analysis
  8. Analyte/formulation stability studies
  9. Small molecule bioanalytical sample analysis
  10. Biomolecule bioanalytical sample analysis
  11. Metals analysis
  12. Pharmacokinetic determinations
  13. Targeted metabolite studies
  14. Analyses and interpretation of PK and PK/PD data
  15. Population PK analysis for optimal dosing
  16. Chemical characterization of small molecules, biotherapeutics, formulated products and botanical extracts
  17. Regulatory development input
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