
Position
Researcher (RTDA)
Contacts
Phone: +39 0498275691
e-mail: alice.sosic@unipd.it
Expertise
- Chemistry of nucleic acids: synthesis, modification, purification of nucleic acids; Enzymatic restriction and ligation of DNA; In vitro transcription of RNA; DNA and RNA Radiolabelling, PCR and real-time PCR
- Aptamers folding, manipulation and applications
- UV-Vis spectroscopy, Fluorescence Spectroscopy, Fluorescence Quenching Assays, FRET and Melting Assays, Circular Dichroism Spectroscopy
- Microarrays: aptamer-based Microarray systems for protein detection, Multiplex Sandwich Aptamer Microarray development and optimization
- Mass Spectrometry (MS): using of ESI-MS via direct infusion nanospray ionization and tandem MS to investigate macromolecular complexes (nucleic acids-protein, ligand-nucleic acids, ligand-protein)
- Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS): detection, quantification and characterization of macromolecular complexes (nucleic acids-protein, ligand-nucleic acids, ligand-protein and ternary complexes) and analysis of their conformational changes via direct infusion nanospray ionization